Season 1

Season 1 of Life with Derek began on September 18, 2005, and Season End On January 22, 2006. Life with Derek Theme song is "Livin' Life with Derek",sung by Cheyenne Twiner of Uncensored, performed by Gary Koftinoff

Season 1: 2005–2006

 * This season was filmed in Corner Brook, Newfoundland and Labrador.

Main cast

 * Michael Seater: Derek Venturi (13-13)
 * Ashley Leggat: Casey McDonald (13-13)
 * Jordan Todosey: Lizzie McDonald (13-13)
 * Daniel Magder: Edwin Venturi (13-13)
 * Ariel Waller: Marti Venturi (13-13)
 * Joy Tanner: Nora Venturi (13-13)
 * John Ralston: George Venturi (13-13)